Serum Irisin Levels in Newly Diagnosed Type 2 Diabetes Mellitus and Prediabetic Patients

Aim: Irisin molecule is in the group of myokins, it is released from muscle cells and a messenger between
muscle and fat tissue. It is shown that irisin peptide has an important role in insulin resistance, glucose and
energy metabolism. In our study we aimed to show irisin molecule's relationship with glucose metabolism.
Patients and Methods: The study included 29 newly diagnosed type 2 diabetes mellitus patients, 41
newly diagnosed prediabetes patients and 28 healthy control groups who applied to the Internal Medicine
Outpatient Clinic between April 2017 and September 2017. Serum irisin levels, laboratory findings and
metabolic parameters were measured and recorded.
Results: The mean plasma irisin level of the type 2 diabetes mellitus patient group was statistically
significantly higher than the prediabetic patients and the control group (p=0.015 p<0.001). Although the
mean plasma irisin level of prediabetic patients was higher than the control group, no significant difference
was found. A statistically significant correlation was found between plasma irisin level and plasma fasting
glucose, HbA1c, total cholesterol, LDL, TG in a positive way and HDL in a negative way .
Conclusion: Our study supports that plasma irisin increases in a compensatory response to the increased
insulin resistance in Type 2 DM patients in a way that regulates glucose metabolism. Although in our
study the mean irisin level in prediabetic patients was higher than the control group, no statistically
significant difference was found between the two groups. Even tough irisin is thought to have positive
results on insulin resistance, studies that larger and consider more different variables are needed in order
to understand its ef fect more clearly .