The Clinical Significance Of Cd38, Cd16, Cd56 And Zap70 Cell
Surface-Antigen Expression In Chronic Lymphocytic Leukaemia
AYNUR UĞUR BİLGİN, SEVİLAY TUNCEZ, İSMAİL REİSLİ
- Year : 2014
- Vol : 30
- Issue : 1
- Page :
1-3
Chronic Lymphocytic Leukemia (CLL) is a disease characterized
by increased number of mature B lymphocytes in blood stream, bone
marrow, lymph node and spleen with different clinical course. In CLL
patients, Rai and Binet classification systems are established for
determination of the necessity of treatment and prediction of survival.
However, the prognostic value of these classifications is limited in early
staged patients. The aim of this study was to investigate the effects
of surface antigens (ZAP70, CD38, CD16 and CD56) in staging and
prognosis of newly diagnosed and untreated patients with CLL. ZAP70
expression was positive in 5 of 35 investigated patients. The majority
of patients with low expression levels of ZAP70 was early stage of
disease and progression-free survival of these patients was longer
than others. CD38 expression was positive in 3 of 35 investigated
patients. The majority of patients with low expression levels of CD38
was early stage of disease and progression-free survival of these
patients was longer than others. In only one patient, both ZAP70 and
CD38 expressions were positive. There was no significant correlation
in patients between the expression of ZAP70 and CD38 CD56, CD16
was expressed at low levels in all patients. The majority of patients
in this study, expressions of surface antigens such as ZAP70, CD38,
CD16 were found as low. Our results are highly significant when
74 % of them are considered to be a early-stage and/or follow-up
without treatment. However, Long-term clinical observational studies
with control groups should be made for understanding the effects of
surface antigens in staging and prognosis of CLL.
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Description :
None of the authors, any product mentioned in this article,
does not have a material interest in the device or drug. Research,
not supported by any external organization.
grant full access to the primary data and, if requested by the magazine
they agree to allow the examination of data.
The Clinical Significance Of Cd38, Cd16, Cd56 And Zap70 Cell
Surface-Antigen Expression In Chronic Lymphocytic Leukaemia
2014,
Vol.
30
(1)
Received : 05.12.2013,
Accepted : 05.12.2013,
Published Online : 13.08.2018
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ISSN:1017-6616;
E-ISSN:2149-8059;