The Effect of Median Dose Alloxan on Rat En-docrine Pancreas and Plasma Glucose Levels

Alioxan is a agent useıl to produce di-abetic animal model with its tavır ejfect on panc-reatic jilet 8 cells. This sıudy was planned to in-vestigate the changes in pancreatic islets and plasma glucose levels afıer the administration of al-kralı. ~an (70 mglkg) were injected jıit-ruvenously to adult Wistar norvegicus rats. At the end of the eighth week, plasmıı glucose levels were determined and pancreatic rslets were invesllgated at the ulırastructural Plasma glucose lere! was 125.1±18.9 in control group while 192±35.5 in experimental group (P<0.001). Pathologic evidenre of toxicity was ııot preseni in exoerin pan•reas. Pancreatic islets were smaller in experimenıal group than in the control. A and D cells at ihe isleıs of Langerhans reınained unaltered, while B cells decreased in ',amber, ha-ving dilated individual profiles of endoplasmi• re-ticulum, decreased secretory granules, and va-ruolated mitocohdrions. This study shows that alloxan has no fark elleri on A and D cells while selectively Imir on B rens of the patıcreatic islets.