The effect of radiofrequency ablation on stem cells and systemic inflammation in patients with supraventricular tachycardia

AHMET LÜTFÜ SERTDEMİR, HALİL İBRAHİM ERDOĞAN, BAHADIR BAHADIR FEYZİOĞLU, MEHMET TOKAÇ, İLKNUR CAN

  • Year : 2019
  • Vol : 35
  • Issue : 4
  •  Page : 225-229

Introduction: Circulating stem cells (CSCs) are released from bone marrow in to the circulation after myocardial injury to improve tissue repair. Radiofrequency ablation (RFA) of cardiac arrhythmias, particularly for atrial fibrillation, has been shown to trigger the release of CSCs through inflammatory mediators. We aimed to investigate whether CSCs are increased in the circulation following non-extensive ablation procedures such as slow pathway or accessory pathway ablations.

Methods: Twenty-six patients [13 females, 54 (18-74) years old] who underwent slow pathway ablation for atrioventricular nodal reentrant tachycardia (n=18) and accessory pathway ablation for atrioventricular reentrant tachycardia (n=8) were included. Peripheral blood CD34+ cell count and multiple serologic markers [troponin I (Tn-I), C-reactive protein (CRP), interleukin-6 (IL-6), stromal cell derived factor (SDF) 1 alpha] were evaluated before the ablation procedure and 7 and 30 days after the procedure.

Results: The CD34+ cell count was significantly increased on the 7th day after the procedure when compared to baseline [33 (15-133) vs. 22,5 (5-79) cells per microliter respectively, P<0.001]. The CD34+ cell count was similar to baseline on the 30th day following the procedure. Levels of Tn-I, CRP, IL-6 and SDF1-α did not change significantly following ablation. The amount of energy applied during RFA (watts) was significantly correlated with the 30th day CD34+ cell count (r: 0.460; p= 0.018).

Conclusions: Peripheral blood CSCs are increased after slow pathway or accessory pathway ablations which are less extensive ablations compared to atrial fibrillation ablation. The levels return to baseline by the 30th day following the procedure. The increase in CSCs was positively correlated with the amount of energy delivered during the procedure.

Cite this Article As : Sertdemir AL, Erdogan HI, .Feyzioglu B, Tokac M, Can I. The Effect of Radiofrequency Ablation on Stem Cells and Systemic Inflammation in Patients with Supraventricular Tachycardia. Selcuk Med J 2019;35(4): 225-229

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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The effect of radiofrequency ablation on stem cells and systemic inflammation in patients with supraventricular tachycardia
, Vol. 35 (4)
Received : 30.09.2018, Accepted : 30.09.2018, Published Online : 03.12.2019
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;