The Effects of Cimetidine and Famotidine on Neuromuscular Transmission and Their Interaction with Gentamicin
Ayşegül Cenik, AYŞE SAİDE ŞAHİN, Ekrem Çiçek, MEHMET KILIÇ, Necdet Doğan
- Year : 1991
- Vol : 7
- Issue : 3
- Page :
321-325
In the present paper, rat phrenic nerve-diaphragm preparations were used to evaluate the neuromuscular blocking activity of gentamicin, an aminoglycoside antibiotic, and of its combinations with histamine 112-recepwr blocking agents, cimetidine and famoti-dine. Gentamicin and famotidine caused partial neuro-muscular blockade when they were used alone, but cimetidine had no effect. There was no interactions between giyen histamine H2-receptor blocking drugs and reduced concentration of gentamicin (10-4M) which does not exert any neuromuscular blockade. However, when the ineffective doses of cimetidine or famotidine are added in the medium, partial inhibi-tion caused by 10-2 M gentamicin attained to complete blockade. This effect can be reversed with the addition of calcium chloride. These results Show that, if the partial blockade is present, histamine H2-receptor blocking agents can greatly compromise the neuromuscular transmission.
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The Effects of Cimetidine and Famotidine on Neuromuscular Transmission and Their Interaction with Gentamicin
1991,
Vol.
7
(3)
Received : 16.11.1991,
Accepted : 16.11.1991,
Published Online : 16.11.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;