THE EFFECTS OF NIFEDIPINE ON PULMONARY ARTERIAL ATRIAL NATRIURETIC PEPTIDE IN CHRONIC HYPDXEMIC PATIENTS WITH PULMONARY HYPERTENSION

MECİT SUERDEM, Hüseyin Şenocak, Ramazan Yiğitoğlu, Ümit Özbek, Sebahattin Ateşal, Ebubekir Bakan

  • Year : 1992
  • Vol : 8
  • Issue : 4
  •  Page : 617-621
Nifedipide was giren, 10 ıng sublingually. ta 21 patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), anıl its ellects on hemodynamics, and pulmonary arterial atrial natriuretic peptide (ANP) level were in-vestigated during right hecin catheterization. The le-reis of ANI' correlaied di•erıly wiıiı metin pul-monary arterial pressure (r=0.50;p<0.05) and ri,.4la atrial pressure (r=0.47,p<0.05). After nifedipine, mi si,fpufleant changes were observed in mean pul-~naly arterial, right atrial, and pulmonar capillary wedge pressure. Ilowever, the nifedipine caused an increase in the media!, pulmonary arterial plasma ANI' levet from 127.9 to 21153 pglınl (p<0.05). These dara indicate that nifedipine is a stimıdus for AN? release in patients with COPD.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
THE EFFECTS OF NIFEDIPINE ON PULMONARY ARTERIAL ATRIAL NATRIURETIC PEPTIDE IN CHRONIC HYPDXEMIC PATIENTS WITH PULMONARY HYPERTENSION
, Vol. 8 (4)
Received : 23.10.1992, Accepted : 23.10.1992, Published Online : 23.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;