THE EVALUATION OF RETINAL NERVE FIBER LAYER THICKNESS BY OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

MEYDAN TURAN, MEHMET KEMAL GÜNDÜZ, MEHMET ADAM

  • Year : 2019
  • Vol : 35
  • Issue : 4
  •  Page : 249-254

Abstract

Aim: We aimed to assess the changes in retinal nerve fiber layer (RNFL) and optic nerve head (ONH) in patients with chronic obstructive pulmonary disease (COPD).

Patients and Methods: Thirty patients having severe COPD and 29 age and sex-matched healthy subjects were enrolled in the study. After a detailed ophthalmic examination, the ONH and RNFL thickness measurements were taken by an optical coherence tomography (OCT) (Stratus OCT-3). Arterial blood gases (pO2 and PCO2) were measured and respiratory functional tests were performed for the staging of COPD patients. The OCT parameters were compared difference between the 2 groups using independent t test, while Pearson correlation analysis was performed to assess the correlations between respiratory functional tests, arterial blood gases and RNFL thickness parameters. A p value less than 0.05 was accepted as statistically significant.

Results: There were no significant differences in optic disc area, cup area and rim area between COPD and healthy subjects (p>0.05). Parameters of mean and superior quadrant RNFL thickness were found to be significantly thicker in COPD subjects (114.52±7.7 µm and 141.07 ±18.2 µm, respectively) compared to the control subjects (107.9±5.4 µm and 131.31±13.6 µm, respectively) (p<0.05). No correlation was found between pO2 and RNFL thickness (r=-0.22, p=0.33). There was a moderate correlation between pCO2 and superior quadrant RNFL (r= 0.53 and p=0.017), and a high negative correlation between FEV1/FVC and superior quadrant RNFL (r=-0.76, p=0.003).

Conclusions: The increase in pCO2 and the decrease in FEV1 / FVC indicate increased hypoxia. Peripapillary RNFL loss associated with RGC death can be masked by hypoxia / ischemia-induced retinal and optic disc edema. Increased mean RNFL thickness in COPD patients was thought to be due to retinal edema associated with increased hypoxia.

Cite this Article As : Turan M, Gunduz MK, Adam M. The Evaluation of Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography in Patients with Chronic Obstructive Pulmonary Disease. Selcuk Med J 2019;35(4): 249-254

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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
THE EVALUATION OF RETINAL NERVE FIBER LAYER THICKNESS BY OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
, Vol. 35 (4)
Received : 26.12.2018, Accepted : 26.12.2018, Published Online : 03.12.2019
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;