The Importance Of Mıcro-RNA’s In Wılms Tumor

AYLİN ORGEN ÇALLI

  • Year : 2021
  • Vol : 37
  • Issue : 1
  •  Page : 90-95

Wilm’s tumor, the most common childhood renal cancer, is a heterogeneous renal tumor in which diffuse anaplastic or negative histology represents poor prognosis. In Wilm’s tumor pathogenesis, a large number of factors remain uncertain. For this reason, the disease continues to be the focus of further research. MicroRNAs are small, protein-encoding RNA molecules that regulate gene expression at post-transcriptional stage. The role of microRNAs in cancer onset and progression has been demonstrated in most solid cancers. MicroRNAs also have a diagnostic potential, and microRNA-targeted treatment is a candidate for an important role in cancer treatment. In Wilm’s tumor, dysregulation of certain key oncogenic or tumor suppressor microRNAs, such as miR-17 ~ 92 cluster, miR-185, miR-204, and miR-483 has been documented. In this study, we will summarize the current evidence about the role of dysregulated microRNAs in the development of the Wilm’s tumor. The possible effects of MicroRNAs on the clinical diagnosis and prognosis of the Wilm’s tumor will also be discussed. Thus, an overview of the future place of microRNAs in the implementation of new treatment options will be presented.

Cite this Article As : Çallı AO. Wilm’s Tümöründe Mikro-RNA Ların Önemi. Selcuk Med J 2021;37(1): 90-95

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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The Importance Of Mıcro-RNA’s In Wılms Tumor
, Vol. 37 (1)
Received : 16.11.2020, Accepted : 16.11.2020, Published Online : 04.03.2021
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;