The İnhibitory Effect of Heparine on Mitosis of İn Vitro Smooth Muscle Cell

BERRİN OKKA, TAHSİN MURAT AKTAN, Kadir İdin, SELÇUK DUMAN

  • Year : 2007
  • Vol : 23
  • Issue : 1
  •  Page : 7-10
Aim: Heparine is used during some clinical situations. We aimed to reveal heparin’s effect on vessel smooth muscle mitosis under in vitro conditions. Material and Method: Smooth muscle cells were obtained from the 4th passage of cryostored cell suspension prepared from rabbit femoral artery in cell culture laboratory. The 5th passage was studied as control and study group for four days by adding heparine to the medium. Final cell number was calculated and statistical comparison was done. Results: In the 5th passage smooth muscle cells, of control (G1) and heparin applied (G2) groups, heparin caused a statistically significant (p<0,05) inhibitory effect on cell mitosis. Conclusion: Heparin inhibits mitosis of vascular smooth muscle cells.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The İnhibitory Effect of Heparine on Mitosis of İn Vitro Smooth Muscle Cell
, Vol. 23 (1)
Received : 01.09.2006, Accepted : 01.09.2006, Published Online : 30.09.2020
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;