The intraocular pressure (IOP) lowering effects of prostaglandins and prostaglandin analogs

Prostaglandins (PG) are very effective ocular hyper-and hypotensive agents in the mammalian eye, with the direc- tion and magnitude of the intraocular pressure (IOP) change varying by species, PG and dose. İt is generally agreed that these drugs reduce intraocular pressure primarily by increasing uveoscleral outflovv. They may also increase trabecular outflovv facility though available evidence is less convincing. İt has been hypothesized that PGs may increase facility of uveascleral outflow in addition to their other mechanisms, but this has not yet been test- ed. Its potent ocular hypotensive action in primates, including man, Prostaglandin F2 alfa has received substantial study as a potential anti-glaucoma therapeutic agent, but the specific PG receptor(s) involved in ali aspects of the response are unknovvn. In studying prostaglandin and prostaglandin analogs, there are a diverse variety of prostanoid receptor selective agonists. These included DP, EP (EP-ı, EP2 EP3), FP, İP and TP receptor selective compounds.