The protective action of ethylenediamine tet-raacetic acid disodium salt against ouabain toxicity in mice.

ERGİN ŞİNGİRİK, İlhan Gültekin, Şerare Atçı, Yusuf Karataş, Firuz Baysal

  • Year : 1997
  • Vol : 13
  • Issue : 1
  •  Page : 8-12
In this study, the protective action of the •he-lating agent ethylenediamine tetraac:etic acid di-sodium (Na2 EDTA) against ouabain intoxication in healthy mice was investigated_ Although Na, EDTA, at the concentrations tested (10. 20. 40 and 80 mgl kg) had no effects alone. it abolished the toxic elfect induced hy 5 mglkg ouabain at the doges of 40 ad 80 mgikg. The toxic elfect of 15mgikg ouabain was also significantly inhihited hy the highest dose of Nal EDTA (80 mglkg). These results suggest that Na2 EDTA has protective action against ouabain to-xicitiy due ta chelation of calcium.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The protective action of ethylenediamine tet-raacetic acid disodium salt against ouabain toxicity in mice.
, Vol. 13 (1)
Received : 13.10.1997, Accepted : 13.10.1997, Published Online : 13.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;