The role of free radicals in the pathophysiology of acute testicular cadmium intoxication.

Ahmet Serel, HAKAN GEMALMAZ, Alim Koşar, Namık Delibaş, Gülsen Aydın

  • Year : 1997
  • Vol : 13
  • Issue : 1
  •  Page : 25-28
Twentv-four male Wistar stı-ain rats esere in-je•ted i mglml nf cadmiunı t.hloride lrrt-iaperitnırealiy for 21 clays and 20 male rats were considered as controls. At the end of 21 clays all nıts were sacrified tn determine antioxidant enzyme (su-peroxide dismutase, catalase and glutathion pe-roxidase) activities and malondialdehide levels of. testis (MDA). Testis cadmium levels wc're de-termined hy atomic absoıption spectrophotomeley, The histopathological changes in the testis WC1*(' also noted. In the cadmium-treated group. the an-tioxidant enzyme activities and the MDA levels were found to be increased when uompared with control group. There was a .vtatistically significant dıf-ference between two groups (p<0.05). All the cad-mium-treated rats showed pathological testicular al: terations. Our results suggested that peroxidative damage and lipoperoxidation might be ı-esponsible for the physiopathology of cadmium-induced tes-ticular damage.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The role of free radicals in the pathophysiology of acute testicular cadmium intoxication.
, Vol. 13 (1)
Received : 13.10.1997, Accepted : 13.10.1997, Published Online : 13.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;