Use of Mechanically Isolated Stromal Vascular Fraction in Different Wound Types

Wound healing is a physiological process consisting of hemostasis, inflammation, proliferation, and
maturation phases. The disruption that occurs at any stage of these intertwined phases is presented to the
clinician as a chronic wound. The stromal vascular fraction, isolated as a part of the aqueous fraction after
enzymatic or mechanical digestion of lipoaspirate, is an important mesenchymal stem cell reserve, as
well as. It is considered a heterogeneous tissue cocktail due to the preadipocytes, endothelial precursors,
immune cells, hematopoietic cells, fibroblasts and pericytes it contains. Because of its proangiogenic,
antiapoptotic, antifibrotic, immunomodulatory, and anti-inflammatory activities, as well as its advantages
in isolation, stromal vascular fraction has lately acquired prominence in current wound therapy. Although
SVF alone is not effective for wound healing, it is a new and effective technology that provides adequate
cell count and viability for proper wound care and wound bed preparation prior to reconstruction and to
minimize surgical failure.