Frequency of consanguinity, karyotype distribution and sex ratio of cases with trisomy 21

Sennur Demirel, AYNUR ACAR, TÜLİN ÇORA, HATİCE GÜL DURSUN, AYŞEGÜL ZAMANİ, HASAN ACAR

  • Yıl : 1998
  • Cilt : 14
  • Sayı : 4
  •  Sayfa : 165-168
This study included 126 Down syndrome cases (81 males and 45 females) who had regular trisomy 21 in 120 cases, chromosome 21q trisomy in 5 and a mosaic karyotype in one case. The ratio of males to females was found to be 2:1 in regular trisomy 21 and 1:4 in chromosome 21q trisomy. The study implicated that trans-locations that were found were mostly matemal in origin. it is alsa noteworthy that the frequency of consanguinity among the parents having children with Down syndrome (21.6%) was not different from the population fre-quency in Konya (23.2%). Moreover, the mean age of ~her having children with Down syndrome was de-termined to be 30.7
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Açıklama : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler.
Frequency of consanguinity, karyotype distribution and sex ratio of cases with trisomy 21
, Vol. 14 (4)
Geliş Tarihi : 10.10.1998, Kabul Tarihi : 10.10.1998, Yayın Tarihi : 06.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;