The Effect of Pinaverium on Isolated Guinea-Pig and Rabbit Stomach Fundus Contracted With Acetylcholine and Its Relation With Calcium

ESRA KISMET ATALIK, H. İbrahim Karabacak, Ekrem Çiçek

  • Yıl : 1995
  • Cilt : 11
  • Sayı : 1
  •  Sayfa : 65-68
In this in vitro study, by using Ca-I-2 -free me-dium, the effect of pinaverium on acetylcholine (ACh) responses induced by cumulative addition. of Ca+2 (10-4 - 10-2 M) was investigated in isolated gu-inea pig and rabbit stomach fimdus. The responses induced with 104 M ACh, Ca+2 -free medium containing 0.77 mM Na7 EDTA, sho-wed a dose-dependent and significant increase by addition of cumulative concentration of Cal-2 . In the presence of pinaverium (10-5M), the maximum response decreased significantly in both pre-parations. It was showed that the inhibition induced by pinaverium was higher in guinea-pig stomach fundus than in rabbit stomach ftmdus (P<0.05). The results suggest that extracellular Ca+2 - int-lux can be inhibited by pinaverium in both pre-parations.
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The Effect of Pinaverium on Isolated Guinea-Pig and Rabbit Stomach Fundus Contracted With Acetylcholine and Its Relation With Calcium
, Vol. 11 (1)
Geliş Tarihi : 15.10.1995, Kabul Tarihi : 15.10.1995, Yayın Tarihi : 15.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;