Selçuk Tıp Dergisi Arşiv

Ejjects of Mn2+ and Cd2+ vere investigated on the contracture induced hy I mM CaCl2 in the iso-lated frog lower oesophageal circular segments in-cuhated irt Ca2+ free Ringer solution containing 20 mM KCl and 0.01 mM Na2EDTA, Roth Mn2+ and Cd2+ inhibited the contractures in a can-•entration dependent manner. Cd2+ was found to be more patent than Mn2+ on the Ca2+ induced c:ont-racture. These findings indicated that Cd2+ and Mn2+ can block Ca2+ entry from extracellular space ta intracellulat- compartment.

In this study, the protective action of the •he-lating agent ethylenediamine tetraac:etic acid di-sodium (Na2 EDTA) against ouabain intoxication in healthy mice was investigated_ Although Na, EDTA, at the concentrations tested (10. 20. 40 and 80 mgl kg) had no effects alone. it abolished the toxic elfect induced hy 5 mglkg ouabain at the doges of 40 ad 80 mgikg. The toxic elfect of 15mgikg ouabain was also significantly inhihited hy the highest dose of Nal EDTA (80 mglkg). These results suggest that Na2 EDTA has protective action against ouabain to-xicitiy due ta chelation of calcium.

Cytogenetical analyses of 275 cases with sus-pecwd ahnormal sexual development were done. Among them Turner syndrome in 20. Klinefelter syndrome in 9, hermaphroditism in 4. gonodal dysgenesis in 1, and testicular feminization in 4 cases were found. Correlation of clinical diagnosis to cytogenetical diagnosis. incidance, and the mec-hanism of disorder were discussed in the light of li-teratures.

in this study. HBsAg pozitiviiy among blood do-nors at the Konya Kızılay Blood Center. detected du-ring 1991 - 1995 were evaluated. In 539 (4.96 %) of total 10.849 Mond donors positi•ity of HBsAg among the soldier donors was 4.93 %. and among the ci-ıriliurt was 5.40 %. HBsAg positivity was found re be 5.18 Tc fay latex agglutination assay du-ring 1991 - 1994 as against 4.38 % reported in 1995 using ELISA tecnique. Blood group A Rh (+) donors had the highest HBsAg positivity rate ( 6.67 %).

Respiratory Syncytial Virus(RSV) is a fi-equent cause of respiratory tract infections in children. In this study. the serological response ta respiratory Syncytial Virus in 126 pediatric patients with lower respiratory infection was investigated hy 1ndirect immunolltıorescence Antibody(IFA) technique for spesific Ig M and 1g G. RSV- Ig M and RSV- 1g G antihodies vere detected in 44.44% and 56.34% of the hlood samples, respectively.

Twentv-four male Wistar stı-ain rats esere in-je•ted i mglml nf cadmiunı t.hloride lrrt-iaperitnırealiy for 21 clays and 20 male rats were considered as controls. At the end of 21 clays all nıts were sacrified tn determine antioxidant enzyme (su-peroxide dismutase, catalase and glutathion pe-roxidase) activities and malondialdehide levels of. testis (MDA). Testis cadmium levels wc're de-termined hy atomic absoıption spectrophotomeley, The histopathological changes in the testis WC1*(' also noted. In the cadmium-treated group. the an-tioxidant enzyme activities and the MDA levels were found to be increased when uompared with control group. There was a .vtatistically significant dıf-ference between two groups (p<0.05). All the cad-mium-treated rats showed pathological testicular al: terations. Our results suggested that peroxidative damage and lipoperoxidation might be ı-esponsible for the physiopathology of cadmium-induced tes-ticular damage.

This prospective study was carried out on 63 cases operated for the lumbar disc herniation, at the Medical Faculty of Selçuk University in 1996 in the first 9 months. All cases were divided into three equal groups :21 cases who had only disc operation was taken as first group, second group of cases re-ceived topical meperidine at the and of the ope-ration while third group of cases were applied me-peridine injected autolog fat graft. The patients were referred postoperatively 1, 3. 5 and 7 th days _according to "Mc Gill Pain S•ala". In this study we wanted to see the effects of the application method of meperidine on pos-toperative pain and comfortable mohilization.

In the literature. results of VEP studies in epi-lepsy appear tü be controversial. This picture is li-kely due tü the technique diverselv used and the re-latively small numbeı- of the patients groups. Pattern-reversal VEP are recorded in 24 patients with photosensitive (FS) discharges in EEG, and other 21 patients with epilepsy. VE? amplitudes show no dUlerences from those of normal control groups. P100 mean latency of non-fotosensitive group is not prolonged in the patients who are un-derınedication, nor is. it in the ones who have not been administered the drugs (valproic acide and carbamazepine) yet. The latency is founded to be normal in FS gı-o-ups. The impression that the effects of the drugs on VEP reflect dğyerently in this group is eliceted. it is considered that the results may indıcate dğferent pathogenetical mechanisirn in FS group.

The elinical features of hor water epilepsy were presented. In the patient generalized and complex partial seizures were seen. Carbamazepin therapy was used.

In order to stratificate the risk of aı-rhythmi• events (AE) such as sudden cardiac death, vent-ricular fibrillation, sustained vertricular tach-ycardia in the first year after myocardial infarction, 62 patients were evaluated with echocardiography, Holter monitorisation and high resolution signal averaged electrocarcliography (H1-RES ECG). Patients were divided into 2 subgroups according ta presence on absence of AE [AE (+): 5 (%8), AE (-): 57 (%92)]. Patients with AE [(mean left ventriculaı-eje•tion fr-action (LVEF): % 48±I 3.5 showed 5 (%100) late potentials (LP). 1 (%20) malign VA and 3 (%60) LV dysfunction with LVEF 5 %40, while the other patients with AE (-) (LVEF % 55±9.7) had 28 (49%) LP (+), 2(%3.5) malign VA ve 7 (%12) LVEF5._%40 (p<0.05, p>0.05, p<0.0I ). During the 1 year follow-up, LP (+) patients (n=33) who had 6 (18%) LVEF%40 and 3(%9) malign VA showed 5 (%15) sudden death, while LP (-) patients (n=29) who had 4 (13.8%) VEF5_%40 but no malign VA, showed nn sudden death (p>0.05, p>0.05, p<0.05). Patients with VA (n=14) who had 1 1(%78.5) LP (+) and 5.(%35.7) LVEF.40 showed 4 (%28.5) sud-den death in the first year after AMI, whereas pa-tients without VA (n=48) who had 22 (%45.8) LP ( +) and 5(%10) LVEF<%40 showed 1 (2%) sudden death (p<0.05, p<0.05, p<0.01 ). Patients with LVEF5_%40 (n=10), who had 6 (%60) LP (+) and 1 (%1 O) malign VA before hospital discharge evolved 3 (%30) sudden death, wheı-eas pa-tients with LVEF>%40 (n=52) who had 27 (%51 .9) LP (+) and 2 (%3.8) malign' VA before hospital dis•-harge, showed 2 (%3.8) sudden death in the one year follow-up period (p>0.05, p>0.05, p<0.01). In conclusion, in the risk stratification of arrhy-thmic events after AM!. alt of the thı-ee methods (ec-hocardiography, Holter, HI-RES ECG) are usefill where HI-RES ECG is more sensitive.

The Stylohyoid syndrome is a clinical o•cuı-ance which is resulted due to elongated styloid process and calcified stylohyoid ligament . The main complaints in the opeı-ated 43 patients with the diagnosis of stylohyoid syndrome were sore thı-oat, foreign body sensation. Evaluation of computerized tomographic findings revealed that elongated styloid process (70.3%) followed hy ligament calcıfication (29,6%) were the ıngior causes of styloid syndrome. Evaluation of the pos toperat ive specimens histopathologically showed the calsite crystal depositions in ligament Postoperative follow- up revealed complete recovery of the complaints in 95.3% of patients

The incidence of myoma uteri coexisting with pregnancy has increased with shifting of the child-hearing years ta the older ages. it has heen recommended tn treat these casus conservatively and ta avoid surgical approach (myo-mectomy) if possible

We present a case of Jessner's lymphocytic in-filtrate of the skin in a 40-year-old man. The patient had non healing ch•onic inflarnmatory erit-hemapustulous lesions on the face and uppeı- pan of the auı•icles. bilaterally. First histopathologic di-agnosis of the patient was "Discoid lupus ery-thematosus". The lesions appeared on the ,face and made a deformity on the nose. In o•der to achieve exact diagnosis and treatment, all the lesions on the face excised and reconstructed hy a split skin grafit. Auricular lesions that were not treated such a this way, heakd spontaneously. Histopathologic exa-mination of the specimen that was excised from the lesion and healthv skin. revealed that the diagnosis is Jessner's lymphocvti• infiltrate. The reason of spontaneous healing of the auricular lesions exp-lained with no exposure of the auricles to sunshine.

Duı-ing a routine screening program for Down's syndrome. a patient was detected tü be in the high-risk group, because the human chorionic go-nadotropiıı level was high and the unconjugated est-riol level was low. An amniocentesis was perfrırmed and the karyotype was 46 XY. However, at deliver), the infant was found to be a male pse-udohermaphrodite due ta 313-01-1 dehydrogenase de-ficiency. We believe that the result of the triple analyte screening can not be related ta this enzyme deficienty.

Routine safety, in the histopathology laboratory is the con•eı-n of everyone working in it. The la-boratory has alwalys heen an area of potential dan-geı-, but it is everybody's ı-esponsibility tü provide a safer working environment. Ahsolute safety oh-viously can never be achieved, but hy concentrating on the frıllowing basit safe working pro•edures, we can perhaps tıy tü approach this.

The effects of both anesthesia and surgical intervention on the defense system have gained importance for patients and anesthetists today. Most of the immune changes seen in patients after surgery are caused either by the direct effect of anesthetic agents or as a result of these drugs contributing to surgical trauma and endocrine response. While the effect of surgery varies according to the size of the operation and the individual's stress response; The effect of anesthesia may vary depending on the breakdown level of the stress response, the immune status of the individual, the time of exposure to the anesthetic agent, the chemical structure of the preparation used and the anesthesia method (1,2,3). Although it has been suggested in many studies that surgical stress may be responsible for immunodepression seen in the postoperative period, some in vitro studies have also observed that anesthetic agents have an effect. The main difficulty in in vivo studies is to distinguish the effects specific to the anesthetic agent and the effects of many intraoperative factors (type-duration of surgery, body temperature, blood and plasma infusions, other diseases, basal immunological status, nutrition) (4,5).

Laparoscopic cholecystectomy (LC) was first introduced in 1987 by Du Bois (1). However, the first publication in literature belongs to Langenbuch from 1882 (2). It became the preferred method in America and Europe after 1990. It has been widely used in our country since 1992-1993. LC has advantages that cause less discomfort to the patient, short hospital stay, no wound problem or minimal, and bring the patient to society and business life in a short time. Cosmetic results are excellent. However, despite these advantages, there are also risks. These are: - The extension of the bile duct combined with the upward traction of the gallbladder can be perceived as a "long cystic duct" as a false impression. - Wound care and labor is less. - The surgeon's eye (ie camera) is at the level of the portal hepatis. - There is no need to retract the liver, colon and edion as in the open. The upper third of the hepatic canal and the liver hilum sometimes cannot be visualized very well. Because there is no "perception of depth". - It is difficult to perceive the distance between the right hepatic canal and the cystic canal. - In open cholecystectomy, we can clearly reveal the intersection of the bile duct associated with the cystic duct. In laparoscopic cholestectomy: the view of the bile duct combined with the camera in the umbilicus is tangential. This should be borne in mind during LC. If necessary, if we turn the lower right trocar to 10 by umbilical laaroscopy and reveal it, the vision becomes more perfect.