Selçuk Tıp Dergisi Arşiv

The effects of excess all-trans retinoic acid on liver tissue were investigated in this study. Tvvelve adult male VVistar rats were used. The animal were divided into three groups. I. group: 20 mg/kg/day all-trans retinoic acid was given to rats (n:4) by oral gavage, during 15 days II.group: 40 mg/kg/day all-trans retinoic acid was given to rats (n:4) by oral gavage, during 15 days III.group: Pats were used as control (n:4) End of experimental study, rats were killed under ether anesthesia. Liver tissues were taken and fixed with Boin’s solution for light microscobic observation. Paraffin blocks were prepared and 5 mm sections were stained diffrent methods. Later, sections were examined with ligth microscope. İn the experimental groups, the cytoplasms of hepatocytes in the peripheral zone of liver lobules were stainless. Excess celi infiltration which were considered activated Kupffer cells, observed at the peripheral zone. Moreover, hepatic lobule structure of experimental groups were destroyed This findings were more serious for intake 40 mg/kg/day all-trans retinoic acid rats.

The protective effect of melatonin and the combination of vitamin C and vitamin E on the brain tissue of rats treated with chlorpyriphos-ethyl (CE) was investigated. The experimental groups were as follovvs: Control group (C), CE treated group (CE), vitamin E plus vitamin C treated group (Vit), melatonin treated group (Mel), vitamin E plus vitamin C plus CE treated group (Vit+CE), and melatonin plus CE treated group (Mel+CE). Vitamins and melatonin were administered to appropriate groups six days. CE was applied only fifth and sixth days. İn CE group, comparing with C group, thiobarbituric acid reactive substances was found to increase, vvhereas antioxidant potential was decreased (p<0, W) in brain tissue homogenates. Superoxide dismutase and glutathione peroxidase activities were high in CE group, comparing with C group (p<0,10). These results suggest that CE may cause oxidative stress in rat brain tissues, this oxidative stress may involve in CE toxicity, and melatonin and the combination of vitamin C and vitamin E may decrease these toxic effects caused by CE.

We have studied on 47 thyroidectomy material that vvere came to Fırat University Medical Faculty Department of Pathology for the determination of proliferative activity. PCNA method vvere applied, normal thyroid(9), adenomatous goiterfl 1), follicular adenoma(7), papillary carcinoma(l6), follicular carcinoma(2) and anaplastic carcinoma(2). Ali cases paraffin sections stained PCNA/cydin monoclonal antibody. Positive painted nuclei vvas evaluated and PCNA indices vvere calculated as percentage. PCNA indices vvere evaluated normal thyroid %0.5, adenomatous goiter %2.1, follicular adenoma %2.6, papillary carcinoma %6.2, follicular carcinoma %15.7 and anaplastic carcinoma %32.2. As a conclution, thyroid carcinomas shovved significantly increased numbers of PCNA positive cells when compared vvith benign thyroid tumors.

İnternal derangement of temporomandibular joint (TMJ) has been described as abnormal relationship beetween the disc, articular eminence, fossa and condyl. İn this study it vvas compared to magnetic resonance imaging and clinical findings of internal derangement of TMJ. Hundered seventy nine joints of hundered patients, who vvere referred from Selçuk University Faculty of Dentistry with daim of internal derangement in their TMJ vvere examined by MRI. Examination vvas performed at closed and opened mouth position in T1, T2, proton vveighted oblique sagittal plane and closed mouth position in coronal plane. These joints vvere joints vvas divided into four groups as normal, reducted (RA), İrreducted (IRA) and with or vvithout degenerative joint changes according to MRI findings. Clinically they vvere classified as in early, intermediate and late stage. Most of the cases vvere in intermediate (%37) and late (%43) stages. İn early, intermediate, late stages the joints vvere determined normal: 66%, 42%, 10%; RA .26%, 44%, 23%; IRA: 8%, 14%, 67% by MRI respectively. İn RA and IRA joints pain 64%, 83%, limited mouth opening 23%, 66%, clicing 62%, 26%, crepition 11%, 39% vvere found by clinical examination, respectively. Degenerative change of osseos component at the joints vvere freçuently seen in the joints vvith IRA and crepitation. İn the clinical examination of TME vvere significant findings. Also the presence of osseos degenerative changes, vvhich could not be determined by clinical examination, are very important. Because they influence the treatment type and effctivity. We think that in determination of TME joint disfunction, clinical examination and MR findings should be evaluated together.

We aimed to investigate the frequency of the anemia seen in the students of Selçuk University in 1999-2000 educational year by this studying. 147 female and 201 male students (total 348) were chosen through the whole university students randomly to The results of this study was in accordance with literatüre as well. represent whole faculty and highschools as before determined the number of students to be investigated. Firstly complete blood count was studied. Peripheral blood smear was done to the findings of anemia. The level of serum iron, iron binding capacity, transferrin saturation, ferritin, B12, folat were established. According to these results, the whole occurance of anemia established was found İn accordance with iron deficiency. The average of red blood cells in giriş was 4,606,530±460,790/mm3, in males 5,167,810±521,256/mm3 and the average of hemoglobin in gir! was 13.8+1.3g/dl, in males 15.6±1.4 g/dl and the average of hematocrit in gir! was 40.7±4.0%, in males 45.2+4.7%. The low average in red blood cells, hemoglobin, hematocrit in females was found meaningfull as statistical (p<0.0001). The average of white blood cells, MCV, MCH, MCHC, RDW and platalets betvveen females and males could not be able to find the meaningfull difference (p>0.05). İn our survey; anemia prevalence ratio in females 6.8%, in males 5.4%, in whole students 6.3% was found. The ratio of females/males is 1.24. Betvveen the two groups could not be able find the meaningfull difference as stastical (p>0.05). The level of serum iron low, iron binding capacity high, transferrin saturation low, serum ferritin low, peripheral blood smear results at the whole occurance of anemia established were in accordance with the iron deficiency. The level of serum B12 and folat were found in normal range.

Tendon transfers enable wrist and finger extension, and stabilize the thumb vvoints in permanent radial palsy. Different technigues of transfer and their modifications have been used so far. İn 14 out of 17 patients with a mean age of 26 years, we restored finger extension using pronator teres. Terun of function was expected in the other 3 patients, and the so called internal splinting operation was performed using only the pronator teres for vvrist extension. Immobilization in a plaster splint for three weeks was used postoperatively, and it was continued as a night splint foranother three weeks. A rehabilitation programme was started at the end of three weeks postoperatively for ali the patients. The man follow-up was 17 months on the average. Functional scoring was done according to the Zachary model and we obtained 11 very good, 3 good, 2 fair and, 1 bad results. Tvvelve patients returned to their former occupations. Fifteen patients were satisfied with the results. We did not encounter any infection postoperatively. The transfer for wrist extension failed in one patient. We obtained good results comprable with the ones in the literatüre using our technique of transfer, meticulous surgery and good rehabilitation. Although not so important, inability to provide radial abduction was the lacking port of the transfer.

AIM: Our aim is to evaluate the rates, indications and complications of cesarean section, to discuss how to reduce rates, indications and complications in Selçuk University Facult of Medicine. MATERIAL-METHODS: VVomen who gave birth in Selçuk University Facult of Medicine Obstetrics and Gynecology Department between 1992-1999 were examined retrospectively. Cesaren rates, indications, complications, mortality and morbidity were evaluated. FINDINGS: Total cesarean rate was % 23.8. 1/3 of this was composed of previous cesarean. Primary cesarean rate was % 25,5. We found an increasing cesarean rate because of previous cesareans with resultant increase in total cesarean rate every year. CONCLUSION: Cesarean rates were increasing every year. Determination of primary cesarean indication more carefully, planning of vaginal birth for previous low seğmeni transverse incisions would decrease cesarean rate.

AIM: Our aim is to evaluate the rates, indications and complications of cesarean section, to discuss how to reduce rates, indications and complications in Selçuk University Facult of Medicine. MATERIAL-METHODS: VVomen who gave birth in Selçuk University Facult of Medicine Obstetrics and Gynecology Department between 1992-1999 were examined retrospectively. Cesaren rates, indications, complications, mortality and morbidity were evaluated. FINDINGS: Total cesarean rate was % 23.8. 1/3 of this was composed of previous cesarean. Primary cesarean rate was % 25,5. We found an increasing cesarean rate because of previous cesareans with resultant increase in total cesarean rate every year. CONCLUSION: Cesarean rates were increasing every year. Determination of primary cesarean indication more carefully, planning of vaginal birth for previous low seğmeni transverse incisions would decrease cesarean rate.

The superior cerebellar artery (SCA) shows the least freçuent variation amongst the arteries in the posterior cerebral fossa according to its origin and localization. Bilateral duplications of SCA at the origin from the basillar artery was observed in 62 years old male cadaver during the routine dissections in the laboratory of Anatomy Department. Informations about these kind of variatons in this region may provide useful background knowledge prior to the neurosurgical operations and also for the evaluation of angiography

Adult onset Still’s disease is a systemic disease of unknovvn etiology. Clinical and laboratory features are not pathognomonic. The diagnosis is difficult and based upon Yamaguchi’s criteria after exclusion of infectious diseases, hematologic process or autoimmune diseases. Treatment is not well codified but steroids represent the most efficient therapy to control fever and systemic manifestations. Search for new treatments and specific markers of adult onset Still’s disease are needed. İn this study, we present the cases of two patients with adult onset Still’s disease and revievv of the literatüre.

Ultrasonography, Doppler ultrasonography and magnetic resonance imaging findings of three cases with choroidal metastasis were evaluated. Two of the cases were women, and one was man. They had pancreas, breast and bronchoalveolar carcinomas, respectively. Two cases presented with blurred Vision. The case with bronchoalveolar carcinoma was detected during the magnetic resonance imaging procedure for cerebral metastasis. İn one of the three patients immediate hypoechogenic, in the remaining two patients hyperechogenic lesions vvhich were protrused to the posterior wall of the globe determined by ultrasography. Doppler ultranography demonstrated that the lesions were vascularised. The lesions were hyperintense in two, and isointense in one case; ali of them were hypointense on T2- vveighted images. İn cases of primary malignancy with eye complaints, radiologic evaluation can be helpful in the elimination of eye metastasis.

Magnetic resonance imaging provides high contrast, anatomic delineation of the neck and is useful for preoperative localization of abnormal parathyroid glands in patients with persistent or recurrent hyperparathyroidism. Magnetic resonance imaging findings of the parathyroid masses are reported in three patients with hyperparathyroidism.