Makale Arama

The aim of the study was carried out to investigate the diagnostic value of the AgNOR to distinguishing betvveen preneoplastic and neoplastic lesions of the endometrium. Retrospective analysis included tissue material obtained from 50 patients with simple and complex hyperplasia with and without atypia and well differantiated endometrial adenocarcinoma. Sections were stained with AgNOR technique. The results obtained indicate that AgNOR counts have statistical significant in differantiating betvveen well differantiated endometrial adenocarcinoma and, simple hyperplasia and complex hyperplasia with and vvithout atypia.

During pregnancy, some structural changes take place in the uterus endometrium These structural changes have been characterized by remodeling and distruption of the extracellular matrix (ECM). Remodelling and distruption of uterine endometrium have importance for a successful implantation and placentation. MMPs are a group of zinc-dependent endopeptidases that degrade a variety of components of ECM and basal membrane. The activity of MMPs occurs as a result of balance between activated MMPs and their inhibitors (TIMPs). Earlier experimental studies indicated that MMPs and TIMPs have essential role in ESM destruction and remodeling while blastocyt implantation and trophoblast invasion during early pregnancy. Therefore, MMPs and TIMPs are crucial to the beginning and continuation of pregnancy.

Metastasis of lobular breast cancer to the reproductive organs is an extremely rare condition. The followup of internal genital metastases for patients who received tamoxifen and chemotherapy after breast cancer surgery has important clinical significance. Here, we introduce such a patient who applied to our hospital and received treatment.

Aim of the recent study is to evaluate the relationship between endometrial sampling indications and histopathological results. Four hundred women who applied to Izmit Maternity and Child Health Hospital, and had endometrial sampling in 2011 were included in this retrospective study. Data was retrieved from patient’s files and pathology archives. Patients were grouped as menometrorrhagia, postmenopausal bleeding, pre-hysterectomy for myoma uteri and cervical polyp. Data was analyzed with a statistical processing program (SPSS). The mean age was 46.4±8.3 years. Indications of endometrial sampling were menometrorrhagia (62.3%), postmenopausal bleeding (22 %), pre-hysterectomy for myoma uteri (9.5%) and cervical polyp (6.2%), respectively. Of all the cases, 139 (55.8%) had menometrorrhagia with proliferative/secretory endometrium, 23 (9.2%) had endometrial hyperplasia and 1 (0.4%) had endometrial cancer for diagnosis. However, in postmenopausal bleeding group, 48 (54.5%) had atrophic endometrium, and 6 cases (6.8%) were diagnosed for endometrial adenocarcinoma. In prehsyterectomy for myoma uteri, 27 (71%) had proliferative/secretory endometrium, and no adenocancer was diagnosed. In cervical polyp group, 10 cases (40%) had endometrial polyps for diagnosis. General speaking, endometrial sampling should be applied in cases with postmenopausal bleeding and cervical polyps, but a more selective treat should be conducted in cases with menometrorrhagia and prehysterectomy for myoma uteri

ABSTRACT

Objective: Endometrial cancer is the most common malignancy of the female genital tract and the fourth leading cancer among women. Our aim is to share the surgical treatment and results of endometrial cancer cases in our gynecological oncology clinic.

Material and Methods: In this study, the records of 164 endometrial cancer patients operated by the same surgical team between 2009-2019 were reviewed retrospectively. The clinical, surgical and histopathological features of the patients are presented here. Four patients who had sarcoma as a result of pathology, 7 patients who underwent complementary surgery and 1 patient with a second primary tumor were not included in the study.

 

Results: The mean age of the patients included in our study was 61.3 and the mean body mass index was 25.8. According to the postoperative pathology results; mean tumor size was 3.4 cm and mean number of collected lymph nodes was 28.8. Lymph node metastasis was observed in 19 patients and all of the metastases were in pelvic lymph nodes. Endometrioid type adenocarcinoma was seen in 81% of the patients. Myometrial invasion > 50% in 81 patients (49.4%). Twenty patients (12.2%) had cervical involvement, 11 patients (6.7%) had adnexal involvement and 28 patients (17.1%) had lymphovascular area invasion. 76 patients (46.3%) were grade 1, 61 patients (37.2%) were grade 2, 19 patients (11.6%) were grade 3. When the patients were staging according to the FIGO system in 2009, 70 (42.7%) stage 1A, 58 (35.4%) stage 1B, 12 (7.3%) stage 2, 3 (1.8%) stage 3A 17 patients (10.4%) were stage 3C1 and 4 patients (2.4%) were stage 4.

Conclusion: Endometrial cancer is the most common gynecological cancer, and it is usually diagnosed at an early stage as a result of early signs. Tumor size, depth of myometrial invasion and histopathologic grade are used to evaluate the risk of the disease, but studies with a higher number of high stage patients will be more useful in determining the risk.