Oxidative Stress in Colorectal Concer (Early Results)

Objective: Oxidative stress is defined as the event that the concentration of reactive oxygen species (ROS) formed in tissue or cells exceeding the antioxidant capacity. Long duration oxydative stress predisposes to cancer development. In this study, the role of oxydative stress in colorectal cancers was searched. Material and Methods: 17 patients withcolorectal cancer operated in Ankara University, Faculty of Medicine, Department of Surgical Oncology and Ankara Numune Training and Research Hospital between 2000-2001 were included in the study. During the operation, 1cm3 of mucosa was harvested from the tumoral and neighbouring healthy tissue just following the extraction of specimen. Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutatione peroxydase (GPX) levels were measured in these tissue samples. Results: Concentration of free oxygen radicals in tumoral and healthy normal tissues were found to be statistically non-different. Conclusion: Oxidative stress in tumoral tissue of colorectal cancers was not different from the normal tissue.