SERUM ELABELA LEVELS IN ACUTE PULMONARY EMBOLIDE

ABSTRACT
Objective: Acute pulmonary embolism is a common pulmonary vascular disease with high mortality, and there is no specific biomarker developed for its diagnosis yet. In our study, we aimed to examine the serum Elabela levels at the time of admission in patients diagnosed with acute pulmonary embolism and the relationship between oxidative stress and Elabela, and the diagnostic value of Elabela.
Materials and Method: Forty-one acute pulmonary embolism patients and thirty-seven healthy individuals for the control group were included in the study. Elabela, Total Antioxidant and Oxidant Capacity levels were measured from the serums of all participants and the results were compared.
Results: Elabela levels were significantly lower, total oxidant and antioxidant capacity and oxidative stress index values were significantly higher in acute pulmonary embolism patients compared to controls. Elabela levels showed a significant correlation with total oxidant capacity and oxidative stress index. There was no correlation between Elabela and D-Dimer and Troponin I values. In the ROC curve analysis for Elabela, the level required for the diagnosis was 220.18 ng /L with a sensitivity of 75.7% and a specificity of 90.2%. The area under the curve was 0.82 and 95% CI was 0.72-0.94 (p<0.001).
Conclusion: In this study, we showed that Elabela levels were reduced in patients with acute pulmonary embolism. We also observed a negative correlation between total oxidant capacity and serum Elabela levels. As a result of the studies, the relationship between the Elabela-apelin/APJ system and platelet aggregation and atherothrombosis is still unclear. The clarification of this pathway will allow the determination of the role of Elabela as a diagnostic biomarker and therapeutic agent for acute pulmonary embolism. For this, larger and more comprehensive studies are needed. Serum Elabela measurement may be easier, quicker and less invasive for the patient if it contributes to clinical diagnosis.
Keywords: Pulmonary embolism, elabela, oxidative stress