Comperative Assessment on Preventing Haemodynamic Response of Esmolol and Fentanyl During Intubation

Aim: We aimed to compare the effects of esmolol and fentanyl on haemodynamic responses during tracheal intubation in this placebo-controlled, prospective and single blind study. Material and Method: The ASA I-II group consisted of ninety patients, whose age ranged between 18-65, were divided into three groups. 150 mg esmolol were given to the first (Group E), 1,5 µg/kg fentanyl to the second (Group F) and 4 ml isotonic to the third group (Group K) by intravenous route. Propofol 2mg/kg and roküronyum 0,6 mg/kg was given during induction then intubation was performed. The systolic, diastolic and mean blood pressure and heart rate were measured and recorded at following times: before and after the induction, before the intubation and 1., 2., 3., 5., 7., 9. and 11. minutes after the intubation. Results: When it was compared between the groups, increasing heart rate of 1., 2., 3. and 5. minutes after the intubation were lower than both Group F and Group K (p<0.05). There were no significant results belonging to the systolic, diastolic and mean blood pressure between the groups (p> 0.05). Conclusion: As a result, in preventing increased heart rate after intubation esmolol was found to be more succcessful than fentanyl, although both esmolol and fentanyl were not found to be sufficient in preventing blood pressures alone.