The role of chromosomal abnormalities on spontaneous abortions

İn this study that was performed on spontaneous abortions refferred to Department of Medicial Genetics of Medical Faculty of Selçuk University, detection of the incidence and type of chromosomal abnormalities in spontaneous abortions was aimed. With this aim; the specimens from 54 spontaneous abortions were successfully cultured and karyotyped by using conventional cytogenetic techniques. 27.8 % of karyotyped abortions were found to have a chromosomal abnormality. Autosomal trisomy was the predominant chromosomal abnormality and accounted for 53.4 % ali abnormal abortions, followed by poliploidy (26.6 %) and monosomy X (20.0 %). Trisomies were consist of trisomy 15, 18 and 21. One mosaic marker was observed in one aborted specimen. Detected poliploidy comprised two triploidy and two tetraploidy. The obtained findings revealed that chromosomal abnormalities have an important role on etiology of the spontaneous abortions and that for this reason cytogenetic examination of aborted specimens is useful for parent of abortions and for physicians.