Makale Arama

Patients with acute rheumatic fever, who were admitted to Pediatric Cardiology Unit of Selçuk University Meram Faculty of Medicine, were studied ret- rospectively to verify the clinical and laboratory profile of the disease. 395 cases were identified among patients admitted to the present institution. Age on admission was 5-18 years (mean 11.3±2.8), they were 213 (53.9%) boys, and 182 (46.1%) giriş. Manifestations included carditis 70.3°%, arthritis 66.5°%, Sydenham’s chorea 22.2%, eritema marginatum 1 °%,subcutaneous nodules 0.7%. Pericardial effusion was occurred in 3.5°%. Mitral insuffi- ciency and aortic insufficiency and aortic insufficiency were occurred in 95.3°% and 46.4°%, respectively. The regur- gitation disappeared in 23.6°% and 33°% of patients with mitral and aortic regurgitation, during follow-up. The caus- ing recurrence was the non-compliance with penicillin prophylaxis.

Acute rheumatic Sever is stili maintaining current vczlue. Rheumatic heart disease is a result of acute rheumatic fever. The case notes of the patients suffering from acute rheumatic fever for the last sıxteen years who attended out patent ciiinics have been retrospectively investigated in order to contibute to the topic and the incidence of acute rheumatic fever and the sequels which occur as a result of acute rheumatic fever.

Aim: In this study, examination of the index of cardiac-electrophysiological balance (iCEB) and of other
risk markers for cardiac arrhythmia in electrocardiography of children with acute rheumatic carditis was
aimed.
Patients and Methods: Forty pediatric patients with acute rheumatic carditis and 40 healthy children
matched in terms of gender and age were retrospectively enrolled in the study between January 2016
and August 2018. Demographic data of all cases were obtained from records. By electrocardiography, P
dispersion (Pd), dispersion durations of QT (QTd) and corrected QT (QTcd), Tpeak-to-end interval (Tpe),
ratios of Tp-e/QT and Tp-e/QTc, and measurements of iCEB and corrected iCEB (iCEBc) were all
compared between the groups. Statistically significant dif ference was accepted as p< 0.05.
Results: In the patient and control groups, mean ages were 11.40±3.48 years and 11.41±3.31 years,
respectively. Both groups had 16 female (40%) and 24 male (60%) children. In the patient group, heart
rate, PR interval, Pd, QTd, QTcd, Tp-e, Tp-e/QT ratio and iCEBc were found to be significantly increased.
Though iCEB level was higher in the patient group, there was no statistically significant difference with
healthy controls.
Conclusion: In children with acute rheumatic carditis, repolarization-depolarization balance may be
impaired. Therefore, in addition to other electrocardiographic risk parameters for arrhythmia, use of
iCEB(c) may also be beneficial. However , further studies on this issue are needed.

Acute rheumatic fever (ARF) is an acquired cardiac disease, that may develop as a non-supurative, late-onset complication of an infection with group A β-hemolytic Streptococcus, such as pharyngitis or tonsillitis, continues to maintain its importance in developing countries, despite it is relatively rare in developed countries. The aim of this study was to review patients, diagnosed with acute rheumatic fever at our center, and to discuss this disease, which is a major health problem in our country, in the light of recent literature data. Files of patients, who referred to Selçuk University Medical Faculty Hospital, and diagnosed with ARF between January 2010 and February 2014, were assessed, retrospectively, and patient demographic data, clinical and echocardiographic (ECHO) features, treatment responses were identified. A total of 65 patients, including 26 (40%) girls and 39 (60%) boys, diagnosed with ARF, with an average age of 11,6 years (5-17 years) at the time of diagnosis, 16 (24.6%), 11 (16.9%), 5 (7.7%) and 33 (50.8%) of 65 patients has also been diagnosed with carditis, arthritis, carditis and (+) arthritis, and silent carditis, respectively. The most frequently referred symptoms are arthritis and arthralgia, with a 59% rate. Although pathological murmurs and innocent murmurs were identified during physical examination in 25 (38.4%) and 21 (32.3%) patients, respectively; 19 (29.2%) patients had no evidence of heart murmur. The most common findings in echocardiographic assessment are mitral insufficiency (MI), aortic insufficiency (AI), and mitral and aortic valve involvement in 14 (21.5%), 10 (15.4%) and 22 (33.9%) patients, respectively. Acute rheumatic fever continues to be a health-threatining condition in our country. Even if there are no pathological murmur in patients referred with arthritis or arthralgia, with an increased level of acute phase reactants; echocardiographic assessment should be taken.

İn this study the role ofoxygen free radicals in the etiopathogenesis of Acute Rheumatic Fever (ARF) in childhood and its relationship betvveen the clinical fındings were investigated. Tvventy three patients with an age range of 5 to 15 years and 25 healthy children were included. Carditis was observed in 17 of the patients. The ROM levels were determined at the time of diagnosis and periodically after than. Oxygen free radicals and its products were measured colorimetrically using dROM's kit (d-ROMs test, Diacron s.r.l. Diagnostics Division, Via Zircone n. 8-58100 Grosseto-İtaly). The plasma ROM level at the time of diagnosis compared to that of control group was found statistically significant (P<0.05). We observed a Progressive decrease in plasma ROM levels at days 15, 30 and 90. The patients with carditis didn't have statistically different plasma ROM levels compared to the patients without carditis. The plasma ROM level at day 90 was stili higher, though unsignifıcant, than that of the control group. İn this study, we conclude that the oxygen free radicals may play an important role in the etiopathogenesis of ARF.