Makale Arama

Aplastik anemia is a rare and severe comp-lication of viral hepatitis. It's mortality rate is al-most 85%. This coplication has been observed most often in association with non A, non-B viruses (es-pecially hepatitis C virus) and also the other he-patitis viruses can cause this complication. We presented a 17 years old male patient who had aplastir anemia associated with hepatitis C virus. Although full hematologic recovery occured in three months but aplastic anemia recurred after 26 months. The patient died of E. roll septicemia ca-used by harmful traditional application.

A number of cases of aplastic anemia have been reported following infectious ıtepatitis. Aplazsa has usually followed non-A, non-13 hepatitis bul on occasion has been associated with types A and B. The aplasia becomes severe and frequently has a fatal outcorne. We presenled two posthepatiiis aplastic anemia patients who were died.

Preliminary diagnoses of 118 patients who applied to our cytogenetics laboratory between 1.1.1988 - 31.1.1989 and the results of the cytogenetic findings were evaluated with the clinic they were sent to. Of the 118 cases examined, 21 of them had Mongolism, 1 of them had Turner syndrome, 3 of them had sexual development disorders, and 2 of them had karyotypic findings suitable for Fanconi Aplastic Anemia. The role of the cytogenetics laboratory in the diagnosis of diseases with chromosomal disorders and the prevalence of these diseases are discussed in the light of the literature.

Clinical, hematologic and cytogenetic findings of two cases were invastigated. One of them was Fanconi's aplastic anemia and other one was Acute Myeloblastic Leukemia associated with Fanconi's aplastic anemia. Chromosomal abnor-malities of these cases and the possible effects of these abnormalities on the progress of the disease and malignancy were ciscussed.