Makale Arama

With the understanding that adipose tissue is not only a passive energy store, but also an endocrine organ, interest in bioactive factors secreted from adipose tissue has increased. Adipose tissue, consisting of pre-adipocytes, macrophages, endothelial cells, fibroblasts and leukocytes, as well as adipocytes, has an important role in systemic metabolic regulation. Chemerin, called tazarotene-induced gene 2 (TIG2) or retinoic acid receptor responder 2 (RARRES2), was first discovered in 1997 in psoriatic skin lesions as a retinoic acid-sensitive gene. It was later determined that chemerin regulates adipogenesis and adipocyte metabolism, with data showing that it alters adipocyte differentiation, expression of important genes in glucose and lipid metabolism, and is classified as a new adipokine. The effects of chemerin in circulating and inflammatory fluids are mediated through receptor G protein-bound receptor chemokine-like receptor 1 (CMKLR1). The increase in the number of clinical trials associated with increased levels of local and / or circulating chemerin in various diseases, from obesity, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), polycystic ovarian syndrome (PCOS) to inflammatory diseases, supports the important roles of chemerin in the pathogenesis of these diseases. Although it is clear that serum chemerin levels increase in these diseases, the mechanisms regulating the expression of the chemerin are not fully understood. More randomized controlled studies are needed to understand the mechanisms of action of chemerin.

Diarrhea goes on to be an important reason of morbidity and mortality in childhood. Rotavirus infections are among the most common casues of severe gastroenteritis in infants and small children. Secondary bacteremia cases after rotavirus have been rarely reported. An eight month of boy was hospitalized due to rotavirus gastroenteritis and moderate dehydration. After his symptoms resolved with intrevenous hydration and probiotic sachet, fever and deteriotation in general condition were realized on the third day and sepsis was diagnosed. He was monitorized in Intensive Care Unit and started ceftriaxone, amikacine, and vancomycine empirically. His blood culture grew Klebsiella oxytoca which was sensitive to ceftriaxone and amikacine. Vancomycine was stopped and other antibiotics were given for totally 14 days. He was discharged when recovered completely. Bacterial sepsis secondary to rotavirus is an important clinical situation. Fever lasting more than 48 hours or fever rising after remission should be alarming. The importance of rotavirus vaccination should be emphasized because of its probable protective effects on disease complications.

The study was aimed to determine the ratio of properly timed vaccination according to national vaccine schedule in two time points. Method: The study was performed in Konya city center at the years 1997 and 2007. The subjects were obtained from children aged 0 to 23 months by using systematic cluster sampling. Also power estimated was received attention in this formula. Sample sizes were 467 and 380 for 1997 and 2007, respectively. The data was collected by observation and inquiry techniques. Results: Proportion of children age-appropriately immunized was 79.9 % for year 1997. However the ratio of properly timed vaccination for the vaccine schedule was only 35.3 %. These ratios for year 2007 were 84.2 % and 63.7 %, respectively. Mother’s age and educational level, children’s age and labor order, having a vaccine card, a history of sickness can be prevented by the vaccine in family members and economic status were related to the national vaccine schedule. Conclusion: We consider following families who have more children for vaccination, bringing to mind vaccination date for children aged bigger than six months and taking some cautions in order to protect vaccination card.

Chest pain is the most common reason of emergency service visits and is analysed in two subdivisions as cardiac and non-cardiac. Pain of cardiac origin is well understood but pathophysiology of non-cardiac chest pain is complex and poorly understood. In this study, we aimed to assess the characteristics of patients and final diagnoses of patienets admitted to pulmonary clinic with chest pain. In our study, we prospectively analyzed 97 male and 103 female in a total 200 patients who admitted to pulmonary clinic with chest pain. Demographic, clinic characteristics, medical and family histories were noted. After their consultation with the relevant clinic within indications their final diagnosis were recorded. According to the results, pain with musculoskeletal origin was the most common, gastrooesophageal reflux the second, chronic obstructive pulmonary disease, asthma and acute bronchitis related chest pain was the third most common reason. In conclusion majority of patients admitted to pulmonary clinics with chest pain mostly are related to musculoskeletal reasons. On the other hand, patients with chronic obstructive pulmonary disease, asthma and acute bronchitis patients especially who are not diagnosed yet may define shortnes of breath and chest tightness as chest pain.

The purpose of this study was to designate the prevalences of Toxoplasma, Rubella, Cytomegalovirus, HBV, anti-HBs, HCV, HIV among first trimester pregnant women and investigate the relationship between age groups, parity. This study included 2900, under 12 gestational weeks pregnant women, ages ranging from 16 to 45 admitted to Bayrampasa State Hospital obstetrics and gynecology outpatient department between November 2011 and February 2013. Toxoplasmosis, rubella, cytomegalovirus, HBV, hepatitis B infection, HCV, HIV was studied in suitable pregnant women and results were analyzed. Age groups, gravida, parity number were questioned. The mean age of the pregnant women participating in the study was 27.78±5.57 (16-45), mean gestation was 2.21±1.39 (1-8), mean parity was 0.78±0.89 (0-5), mean gestational age on admission was 8±3 (5-12). Toxoplasma IgG, Rubella IgG, Cytomegalovirus IgG, HBsAg, antiHBs, HCV, antiHİV seropositivity were respectively 31.2%, 95.7%, 99.2%, 2.4%, 22.1%, 0.1%, 0%; and Toxoplasma IgM, Rubella IgM, cytomegalovirus IgM seropositivity percentages, were respectively 0.9%, 0.15%, 0.7%. Toxoplasma seropositivity rate is similar to Turkey data. Rubella seronegativity was found lower then the data of Turkey and with the prepregnancy vaccination this value can be pulled the level of European countries. The high level of CMV seropositivity in our study indicates the low socioeconomic status. HBsAg, anti-HBs, anti-HCV and anti-HIV levels were close to the average of Turkey. According to them, in addition to routine screening of TORCH, screening for HBsAg and anti-HBs appears appropriate, anti-HCV and anti-HIV screening is not cost effective.

Neonatal hemochromatosis is a rare disease clinically defined as severe neonatal liver disease in association with extrahepatic siderozis. The etiology of neonatal hemochromatosis is not understood exactly. However, according to a theory neonatal hemochromatosis is accepted to be an alloimmune disorder causing liver injury in fetus. After an effected one in the pregnancy the recurrence rate of neonatal hemochromatosis is ~80%. Hepatocellular failure which occurs in the first days of life with coagulopathy, hypoglycemia, hypoalbuminemia, hypofibrinogenemia, thrombocytopenia, anemia, and direct and indirect hyperbilirubinemia characterizes neonatal hemochromatosis. In order to diagnose neonatal hemochromatosis there are some certain criteria that sould be taken into account such as a positive family history, high serum ferritin levels, high serum alpha-fetoprotein levels and siderozis demonstrated with histology or with magnetic resonance. Since an affective medical treatment has not been found yet, liver transplantation is almost always required. The prognosis of neonatal hemochromatosis is generally poor. This review will discuss neonatal hemochromatosis that leads to liver failure in the fetus or newborn.