Makale Arama

Skeletal muscle metastasis from non-small-cell lung cancer (NSCLC) is a rare event and the optimal treatment strategy is still unknown. Herein we report a case with biceps metastasis from NSCLC. A 50-year-old man with a distant biceps metastasis due to NSCLC is presented. One month after chemo-radiotherapy and adjuvant chemotherapy the patient was readmitted with a painful mass located on the right biceps brachii muscle. A biopsy of the painful mass disclosed the muscle metastasis pulmonary adenocarcinoma. The patient was treated with palliative radiotherapy and systemic chemotherapy was planned. At the end of the palliative radiotherapy his pain was disappeared. Two months later (18 months after the diagnosis) the patient died of respiratory failure. Palliative radiotherapy may be a good treatment option for patient with muscle metastasis from NSCLC.

Aim: The aim of this study was to evaluate the prognosis value of tumor size and preoperative albumin levels in gastric cancer patients treated with postoperative chemoradiotherapy. Patients and Methods: Patients records reviewed retrospectively. Clinicopathologic features were analyzed. 199 patients who applied to our clinic between 15.1.2010-31.12.2016 were included in this study. The primary end points of this study were to evaluate the overall survival (OS) and the disease free survival(DFS). Results: Mean follow up time was 20.43 months. Distant metastases devoloped in 50 patients and 102 patients were alive. In multivariate analyses , advanced T stage, history of smoking, preoperative albumin level less than 3.5 gr/dl and tumor size more than 8 cm were found to have poor prognostıc effect on OS. Lymphovascular invasion (LVI) and tumor size were showed negative effects on DFS. For statistical analyses SPSS( statistical package for social sciences) 21.0 statistical package was used. Conclusions: Despite recent treatment modalities the prognosis of gastric cancer is still poor and novel prognostic factors together with the current ones may be helpful to predict decision of proper treatment modalities and survival of the patients

Purpose: Laryngeal squamous cell carcinoma poses a management challenge due to the lack of reliable prognostic markers. Although tumor budding (TB) has been shown to predict poor prognosis in some malignancies, its prognostic significance in laryngeal cancer remains uncertain in the literature. Therefore, the objective of this study is to evaluate the impact of TB on prognosis and its correlation with other established prognostic factors in laryngeal squamous cell carcinoma.

Patients and Methods: In the department of otolaryngology the files of 60 patients with laryngeal squamous cell carcinoma who underwent surgery, postoperative chemoradiotherapy between 2008 and 2015 were analyzed retrospectively. The patient’s history, family history, age, TNM (tumor, node, metastases) classification, radiological imaging, type of surgery performed, and the results of the pathological specimen were evaluated. PanCK immunohistochemical staining was performed on old paraffin block sections containing tumoral tissue, previously stained with Hematoxylin & Eosin. The TB scores were evaluated by the pathology department, and the association between all obtained parameters and clinicopathological variables was analyzed.

Results: Our findings showed a significant association between tumor budding and perineural infiltration, a known prognostic factor for laryngeal carcinoma (P=0.006). TB was found to be an independent risk factor for perineural infiltration and pathological lymph node involvement (p=0.003). Pathological lymph node involvement was also found to be an independent risk factor for lymphovascular invasion (p=0.028).

Conclusions: Our study provides evidence for a significant association between tumor budding and perineural infiltration, which are established prognostic factors in laryngeal carcinoma. This suggests that tumor budding may be an important factor in determining tumor prognosis.

Colorectal cancer remains a significant health problem today. In parallel to the developments in the field of surgery, improvements in adjuvant and neoadjuvant treatment modalities lead to increase in both local control and overall survival times. The main purpose of this review is to discuss the current treatment options of rectal cancer with literature data. Surgery is an essential treatment option for rectal cancer. Treatment success for rectal cancer has been increasing by the help of neoadjuvant (preoperative) or adjuvant (postoperative) modalities. According to the recent studies, preoperative (chemo) radiation therapy is superior to postoperative treatment in terms of local control and sphincter preservation. However, there is not enough data regarding to the difference between the efficacy of shortterm preoperative radiotherapy and long-term chemoradiotherapy. Today, for the treatment of rectum cancer, preoperative (chemo) radiotherapy is superior to postoperative (chemo) radiotherapy in terms of overall survival and local control. However, new prospective randomized trials should be designed to compare the short term and long term preoperative (chemo) radiotherapy.

Aim: Investigate the role of Magnetic Resonance Imaging (MRI) in the evaluation of response of the locally
advanced rectal cancer to the chemoradiotheraphy (CR T).
Patients and Methods: T2-weighted and Diffusion Weighted Imaging (DWI) of 24 cases with locally advanced
rectal cancer who have undergone total mesorectal excision 6-8 weeks following the CRT between 2015 and
2020 were evaluated retrospectively. The evaluated radiological parameters were as follows; Tumor morphology,
localization, length, mrT/mrN stages, and extramural vascular invasion (EMVI). Post-CRT MRI residue scoring
was performed (0: No residual tumor, 1: No significant residual tumor, fibrotic wall thickening, 2: Residual tumor
present). Regression grading was as follows; 1: No tumor, 2: Good response, mostly fibrosis, 3: Fibrosis and
mucin more than 50%, 4: Slight response, 5: No response.
Results: There was a significant decrease in the craniocaudal length of tumor and a significant increase
in the mean ADC of tumor after CRT (p=0.001). A significant and high correlation was observed between
histopathological T (pT) and post-CRT mrT (r=0.54, p=0.006). There was a significant correlation between pre-
CRT EMVI and perineural invasion (PNI) (r=0.53, p=0.008). A significant correlation was found between residue
scoring and regression grading (r=0.6; p=0.001), pT (r=0.48; p=0.02), and tumor length (r:0.51; p=0.01). There
was a significant correlation between regression grading and EMVI (r=0.43, p=0.036), PNI (r=0.46, p=0.02), pT
(r=0.41; p=0.048), pN (r=0.55; p=0.006), and metastatic/total lymph node ratio (r=0.46; p=0.02).
Conclusion: Post-CRT MRI is highly correlated with postoperative pathological evaluation of the locally
advanced rectal cancer. MRI is highly successful in re-staging as well as primary staging. The evaluation of
treatment response by MRI regression grading may contribute to the surgical planning.