Makale Arama

Aim: In autologous breast reconstruction, there is pain in the recipient site due to rib cartilage intervention in the postoperative period. In this study, we aimed to reveal the effect of the rib-sparing internal mammarian vessel approach on postoperative pain in breast reconstruction by comparing it with the noncostal-sparing approach.
Patients and Methods: Between 2018 and 2022 twenty five patients underwent surgery were included in the study. Groups were divided according to internal mammary artery(IMA) exposure techniques. Group 1: Patients who underwent rib-sparing surgery(n=9), Group 2: Patients who underwent rib cartilage resection(n=16). Patient Controlled Analgesia(PCA) pump usage time, morphine dose used, and early and late pain scores were noted in both groups in the postoperative period.
Results: The mean age of the patients was 49.8 years. No complications were encountered in the early and late postoperative period. All flap transfers were successful. Mean PCA duration was 24±1.41 hours in group 1 and 26.31±1.62 hours in group 2. The dose of morphine was 9.67±1 mg in group 1 and 23.93±3.02mg in group 2. The early pain score was 2.89±1.16 in group 1 and 5.18±1.22 in group 2. Late pain scores were 2.11±0.98 in group 1 and 2.75±0.77 in group 2.
There was a statistically significant difference between the morphine dose and early pain scores of the groups (p<0.01). There was no significant difference between the duration of PCA use (p=0.3) and late pain scores (p=0.07) (p>0.05).
Conclusion: In conclusion, we think that costal sparing surgery significantly reduces pain in the early period during recipient site preparation in autologous breast r econstruction.

Nowaclays in some cases we come across that the patients feels what happens at the operation. In our study we search the preventive effect oj larozepam and morphine ta this position. As a result we come to a conclu-sion thet larozepam is rnore effective than morphine.

Aim: Morphine is one of the most preferred opioids in treatment of chronic pain. Recurrent use can
cause addiction. There is no consensus on cardiovascular system treatment/side effects of opioids. In
order to investigate effects of opioid addiction on heart, myocardial contractility/histological changes were
investigated in rats via experimental morphine addiction/withdr awal.
Materials and Methods: 32 adult male Wistar albino rats used for study, which was officially completed
on 28-05-2021, were divided into Control(C), Morphine(M), Morphine+Naloxone(MN) groups randomly. In
GroupC 10mg/kg 0.9% NaCl solution, in GroupM-MN 10mg/kg morphine were administered subcutaneously
for 7 days. After the last administration of morphine, 3mg/kg NaCl was given to GroupC-M, 3mg/kg naloxone
was given to GroupMN intraperitoneally. Signs of morphine withdrawal were observed for 30 minutes
and scored. 3-4mm strips of atria were hung in isolated organ bath chambers. Tension was adjusted to
2g. Adrenaline-induced contractions (0.001M) were observed. Changes in tension were recorded. SAS
University Edition 9.4 program was used for statistical analysi s.
Results: Morphine withdrawal behaviours were observed in GroupMN. There was no statistically
significant difference between atrial contractility tension values of GroupC-M-MN(p>0.05). Pre-adrenaline
tension values were higher in GroupM-MN than in GroupC. But the greatest contraction increase between
15minutes before/after adrenaline-induced data was in GroupC.
Conclusion: Morphine addiction/withdrawal didn’t cause inotropic/chronotropic changes. No histological
differences were observed in mast cells. These results may constitute a positive resource for the heart for
systems analysis in morphine addicts.

Aim: The aim of this study was to evaluate the effects of intraarticular administration of sufentanil and morphine on postoperative pain and analgesic requirements after artroscopic knee procedures. Material and Method: Sixty patients scheduled for artroscopic knee surgery were randomised into three groups. A standart general anesthesia was used for all patients At the end the surgery , before the artroscope was removed the following solutions were administerd in 20 ml of normal saline. Group I:(n:20) 20 ml normal saline, Group II:(n:20) 10mg sufentanil, Group III:(n:20) 2 mg morphine. Awaken time of the patients was estimated as time 0 and Visual Analog Scale (VAS) scores were assesed. IV PCA (Patient Controlled Analgesia) was given as tramadol. The PCA deliveries at 30 min, 2 hours, 12 hours and 24 hours and total tramadol requirements for 24 hours were noted. Result: VAS scores were significantly lower in group II(p< 0.05). The consumption of tramadol at 30 min was also lower in group II when compared to group I and group III (p<0.05). Intraarticular sufentanil significantly reduced the postoperative consumption of analgesics (p<0.05). Conclusion: As a result we concluded that intraarticular sufentanil using in artroscopic knee procedures is simple, effective, safe and well tolerated analgesic techinique. This study showed that the onset of analgesia was faster and stronger with intraarticular sufentanil.

İn this study the effects of low-dose morphine hydrochlorur on rat kidney vvere determined at light microscopical level. A total of 30 Sprague Davvley rats from both sexes (15 male and 15 female) vvere used. Five rats from both sexes vvere served as Controls, vvhereas 10 rats from each sex vvere used as experimental group. Control animals vvere injected subcutaneously vvith physiological şaline (5mg/kg), the animals of experimental group vvere given morphine hydrochlorur at a dose of 5 mg/kg in every other day. At the end of the experiment, the animals vvere perfused vvith buffered formaline (pH=7.4) under anaesthesia, and kidneys vvere extirpated, and morphometrical measurements (thickness, height, length) vvere taken. Follovving, kidney samples vvere processed by means of routine histological techniques and the sections vvere taken at 7pm thickness, and stained. Slides vvere then examined using light microscope. The investigations have revealed that the low-dose-morphine hydrochlorur caused to glomerular destruction, epithelial necrosis and desquamation in both proximal and distal tubuli, vascular hyperemia and hemorrhagies. Based on the findings, it was concluded that the results of this study might be specific to the rat kidney vvhich is devoid of detoxification enzymes in tubuler epithelial cells and a study should be performed on an animal having similar metabolism with human.

Drugs in this group often have a depressive effect on the central nervous system and more or less all of them have the potential to cause Hag addiction. Narcotic analgesics do not have anti-typiretic and anti-inflammatory effects. Opioids have been used for hundreds of years to relieve pain caused by surgery, to relieve pain in patients with chronic pain, and to alleviate anxiety. It is not used only for premedication, but also as an analgesic after surgery and anesthesia. Substances of the opiate word such as morphine, codeine and papaverine obtained only from papaver somniferum. The opioid word is more appropriate to refer to the complete group.

In this ligin microscopic study, the ellects of morphine sulfate on nasal mast celis was in-vestigated using alcian blue-safranin O and to-luidin blue staining methods. The investigation was peıformed on 20 m❑le and female albino rats which were obtained from the E.xperimental Animal Laboratory of the Faculty of Medicine, Selçuk University. Rats were divided int° two groups of ten rats each. First group was considered as control group. Percutaneous injection of 200 ıngikg morphine sulphate was administered to the second group. Rats were anesthetized by ether and regio res-piratoria nasi of rats were frontally excised. Tissues were fued in Carnoy solution for three days at room temperature, dehydrated with absolute al-cohol and eınbedded in parallin. Five micrometer sections were eut from the paran blocks using ro-tary microtome and stained with alcian blue-safranin O and toluidin blue solutions. In conclıtsion, control group slides demostrated normal appearing mast rens with dark violet (with toluidin blue) and red and reddish-hlue (with alcian blue-safranin O) stained granules. In contrast, the ınorphine sulphate stimulated specimens exhibited no granules.