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Malıgn Plevral Efuzyonlarda Cea Ve Ca 19-9 Duzeylerı
Adil Zamani, Gülden Paşaoğlu, Ümmügülsüm Can, Faruk Özer, Mehmet Gök, Oktay İmecik
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Malıgn Plevral Efuzyonlarda Cea Ve Ca 19-9 Duzeylerı
Cea And Ca 19-9 In MalIgnant Pleural Ef-FusIons
Seljuk Universitesi Ttp Fakiiltesi Gogiis Has-taltklart ye Tiiherkiiloz Anabilim Dalinda 1994-1995 yillart arasinda yattrzlarak tetkik edilen 89 plevral efiizyonlu ve 25 saghkli hirey calqmaya alindi. 01-. gular etyolojik tat-taw-ma gore malign ye benign ola-rak iki gruha ayrildt. Toplam 89 olgudan 35'i ma-lign, 54'il benign gruptaydi. Malign gruhun yac ortalamast 64±10.54 olup 24'ii erkek. kadm be-nign gruhun yac ortalamast 47.94±15.56 olup 34'ii erkek, 20'si kadmdt ye kontrol gruhun yak or-talantast 45.28±11.71 olup 12'si erkek, 1 kadinds. Pleural efiizyonlu hastalarm serum ye plevral si-vtlarinda CEA ye CA 19-9 degerleri ye plevral mil serum oranlart; kontrol gruhunda ise hu tumor be-lirleyicikrinin (TB) serum degerleri okiilerek ma-lign kaynaklt eftizyonlart saptamakta serum ye plev-ral sty, degerleri arasindaki ili ki argttrildt. Malign olgularda CEA'nin serum degerleri benign grup ye kontrol gruhundan istatistiksel olarak anlamIt de-recede yiiksekti (p<0.01 ye p<0.001). Pleural sly, degerleri ye plevral stvilserum oranlari malign grupta anlamh derecede yiiksekti (p<0.01). CA 19- 9'un serum degerleri normal olmastna ragmen plev-ra sty, degerleri malign grupta benign grup ye kont-rol gruhuna gore a►lamli derecede yiiksekti (p<0.005). Sonuy olarak malign efiizyonlart sap-tamada CEA ye CA19-9'un serum degerlerine ha-ktlmadan sadece plevral stvt degerlerinin yeterli olabilecegi sonucuna varildt.
This study was performed in consecutive 89 pa-tients with pleural effusions and in 25 healthy in-dividuals chosen as a control group. The patients were separated in two groups according to their ae-tiologies: malignant pleural effisions and benign pleural effusions. In 35 cases, the cause of pleural effusions was malignancy and in other 54 cases there were benign diseases. The levels of CEA and CA 19-9 were measured in serum and pleural fluid of all patients and in sera of control group. We also investigated the relationship between serum and ple-ural fluid CEA and CA 19-9 concentrations. Mean serum and pleural fluid CEA concentrations was higher in malignant pleural effusions than in benign pleural effusions than in benign pleural effusions and healthy groups (p<0.01 and p<0.001). The lev-els of CA 19-9 in pleural fluid was higher in ma-lignant pleural effusions than in benign elisions (p<0.005). In conclusion, this study demonstrated that CEA and CA 19-9 pleural fluid levels might he useful in differential diagnosis of malignant pleural
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