Makale Arama

Purpose: Laryngeal squamous cell carcinoma poses a management challenge due to the lack of reliable prognostic markers. Although tumor budding (TB) has been shown to predict poor prognosis in some malignancies, its prognostic significance in laryngeal cancer remains uncertain in the literature. Therefore, the objective of this study is to evaluate the impact of TB on prognosis and its correlation with other established prognostic factors in laryngeal squamous cell carcinoma.

Patients and Methods: In the department of otolaryngology the files of 60 patients with laryngeal squamous cell carcinoma who underwent surgery, postoperative chemoradiotherapy between 2008 and 2015 were analyzed retrospectively. The patient’s history, family history, age, TNM (tumor, node, metastases) classification, radiological imaging, type of surgery performed, and the results of the pathological specimen were evaluated. PanCK immunohistochemical staining was performed on old paraffin block sections containing tumoral tissue, previously stained with Hematoxylin & Eosin. The TB scores were evaluated by the pathology department, and the association between all obtained parameters and clinicopathological variables was analyzed.

Results: Our findings showed a significant association between tumor budding and perineural infiltration, a known prognostic factor for laryngeal carcinoma (P=0.006). TB was found to be an independent risk factor for perineural infiltration and pathological lymph node involvement (p=0.003). Pathological lymph node involvement was also found to be an independent risk factor for lymphovascular invasion (p=0.028).

Conclusions: Our study provides evidence for a significant association between tumor budding and perineural infiltration, which are established prognostic factors in laryngeal carcinoma. This suggests that tumor budding may be an important factor in determining tumor prognosis.

In this study, thirty cases af laringeal carcinoma which diagnosed in our clinic between November-1994 June-1996 are compared by preoperative CT, laryngoscopy and postoperative speciemen findings. By laryngoscopy one could evaluate the status the mucosal lining and vocale cord motility. Lımitations of the cord vocale motility is attributed to deep invasion of the tumour but, the exact dimensions of the tumour could not be estimated. The conventional radiologic examination methods da not add any useful knowledge to the laryngoscopy. The com-puted tomograpic examination is useful to determine the precise anatomic localization and spread of the tumour which is very useful ta surgeon to choose the surgical treatment method. We concluded that CT is valuable di-agnostic method in evaluating the preepiglottic area, paraglottic area, subglottic area and the inferior areas of the larynx which is obstructed by the large laryngeal masses and the cartilage invasion which could not be evaluated by laryngoscopy and other conventional radiological methods. Also we concluded that there may be wrong de-cisions about the cartilage invasion due to the irreguler calcifications and microinvasions by CT examination. In the evaluation of the small mucosal lesions CT could yield false negative results and these lesions could be more accurately determined by laryngoscopy. CT evaluation of the laryngeal carcinoma patient prior to surgical in-tervantion is an additional diagnostic tool to the laryngoscopy and very useful for the determination of the best conservative surgical method.

110 patients were treated with surgery for lary-ngeal cencer between 1983-1993. Results were com-pared with literature.

134 patients admitted to our clinic with laryngeal cancer were evaluated. The factors that play a role in the etiology of laryngeal cancers and the localization of my lesion in my larynx were compared with the literature.