Makale Arama

The intracaviter mitoxantrone was applied to the 14 patients who was evaluated having grade 1 and 2 transitional cell carcinoma in the pathologic examinations by using transurethral resection for the bladder tumor in our Mean follow-up period was 13 months (range 3-19 months). Any systemic complications and chemic cystitis sings weren't enough to determine the period without tumor,since they didn't cause any chemic cystitis and only one patient had recurrence, they found very hopeful.

Anal submucosal methotrexate was applied ta totaly 5 patients; one women and 4 men with transi-tional cell carcinoma which was evaluated that it was inoperable between the dates of july 1990 and july 1991 in the urology department of Konya Selçuk Medical Faculty. The aim of applying anal submu-cosal was to provide drug involments with high con-centrtions in the bladder rather (han its being system-ic by making use of the venous comminications between anal sanal and the bladder. CT, ultrasound and endoscopic examinations proved that these applications had been useful mark-edly. Any complications hadn't been observed due to drug applications on the application area because of injections.

Aim: The purpose of this study was to investigate the value of contrast material-filled virtual cystoscopy in the detection of bladder tumors. Material and method: Thirty-six consecutive patients (28 male and 8 female; range age, 51-82 years; mean age ± SD, 65 ± 7 years) who had painless hematuria and suspected to have bladder neoplasm prospectively evaluated with virtual cystoscopy. After the intravenous injection of contrast medium, the contrast material-filled bladder was examined with single detector helical computed tomography (CT) scan with 2-mm slice thickness. Source CT data were transferred to a workstation for interactive navigation using surface rendering. All patients also underwent conventional cystoscopy. The results of virtual cystoscopy were compared with the findings of conventional cystoscopy. Results: Seventy-one of 78 bladder tumors detected with conventional cystoscopy in 28 patients were also shown on virtual images. Five patients had a normal appearance on both conventional cystoscopy and virtual cystoscopy. On virtual cystoscopy, seven of the 12 lesions 5 mm or smaller in diameter could be identified. We found the following statistical values for the identification of bladder lesions on virtual cystoscopy: sensitivity, 94%; specificity, 90%; positive predictive value, 87%; negative predictive value, 93%; and accuracy 93%. Conclusion: CT virtual cystoscopy is a noninvasive technique which is used successfully for detection of bladder tumors larger than 5 mm.

In our clinic 6 patients (One of diem was a lady) were te!:eıı under control with the aspeci that they had bladder tumors. Their anorectums were normal anJ their radiographies were taken at the 15 th, 30 th, 45 th, 60 th and 120 th minutes after injecting 7 mi contrast substance to their ana! submucosa. After injection, it was observed that prostatic ple.xas and whole bladder wall became opasify within 30 min-utes. Even 2 hours lazer, no contrast was observed in the pyelocaliceal system and ureters. It was understood that anal cystography was a helpful diagnose method in the evaluation of pathol-ogies which invaded the bladder wall and prostate.

Tc-99m labelled cyclophosphlamide was adminis-tred to 10 rabbits intravenous, 10 rabbits by anal submucosal injection. The rabbits were sacrified after 5 hours following injection and radioisotopic counts ıvere made from liver, kidney and bladder tissue by gamma camera scanning. The result were evaluated with student's t test. The drog accurnulation in vesi-coprostatic plexus and bladder tissue following anal submucosal injection was found high were as liver, kidney concentration were low, on the contrary intravenous injection.

During 1996 and 1999, we applied MVAC in 27 patients whose final stage bladder tumor depends on pathological and radiological bases at urological department. 15.4 % had complete response, 34.6 % had partial clinical response, 34.8 % hadn’t any clinical response and 19.7% had progression. One of the patient died due to a wide spreed tumor metastasis and neutropenic sepsis during the treatment. The most common side-effects were nausea- vomiting, transient renal failure, leucopenia, and trombocytopenia. M-VAC therapy showed it’s beneficial effect by decreasing the stage so providing TUR possibility and other alternative surgical procedurs.

For 15 patients with superficial bladder tumor suffering from hematuria, dvsuria, pollacuria, ur-gency have been reffered our clinic applied tran-surethral resection between March 1993-June 1994. Second transurethral resection was performed approximated)! 1 month after the initial Iran-surethral resection in cell patients b) same urologist. In 7 patients of 15 patients residual tomtit- was con-firmed hitologically at resection area after second TUR. It was understood that second transurethral re-section performed determined interval in patients H.,ith superficial bladder tumors succesfid alternative-for prevent and confirm of residual tumor.